Men and postmenopausal or sterilised women who have osteoarthritis of the knee needed for the study of a potential new medicine to treat the condition. You must be 40 to 75 years old and have a BMI between 19 and 34.9. Vegetarians and smokers are allowed. The study involves 4 screenings, 18 study visits, 2 additional visits for Covid-19 tests, and 1 telephone call. Start date to be confirmed.